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Phases of Pathophysiology of Chronic GVHD

The expert panel explores the immunological aspects of chronic GVHD, highlighting challenges in simultaneous management, addressing fibrosis, and emphasizing the importance of early intervention in evolving transplant care practices.

Dana farber cancer instituteUnited statesMitchell horwitzCorey cutlerHannah choeBin chenProfessor of medicine at harvard medical schoolOhio state universityCell therapy program at massachusettsMarrow transplant program at duke universityCell therapy programMassachusetts general hospitalHarvard medical schoolStem cell transplant programAdult bloodMarrow transplant program

Acute Versus Chronic Graft-Versus-Host Disease (GVHD)

Drs Yi-Bin Chen, Corey Cutler, Hannah Choe, and Mitchell Horwitz distinguish acute from chronic graft-versus-host disease (GVHD), how such distinction has changed over the last decades, and provide an overview of consensus definitions for disease grading.

Dana farber cancer instituteUnited statesMitchell horwitzCorey cutlerHannah choeBin chenMarrow transplant program at duke universityOhio state universityProfessor of medicine at harvard medical schoolCell therapy program at massachusettsCell therapy programMassachusetts general hospitalHarvard medical schoolStem cell transplant programAdult bloodMarrow transplant program

Obinutuzumab Use Decreases Incidence of Steroid-Requiring cGVHD After Transplant

Utilizing obinutuzumab to enhance B-cell depletion significantly reduced the need for corticosteroids and increased relapse-free survival in patients with steroid-requiring chronic graft-vs-host disease undergoing well-matched hematopoietic stem cell transplant.

Dana farber cancer instituteUnited statesCorey cutlerStanford universityNational institute of healthFritz laboratoryNational instituteB cell depletionChronic graft vs host diseaseHematopoietic stem cell transplantPhase 2 study nct028673842023 ash annual meeting

B-Cell Depletion With Obinutuzumab May Prevent GVHD

Researchers determined obinutuzumab administered after HSCT resulting in B-cell depletion was associated with lower rates of chronic GVHD.

Dana farber cancer instituteUnited statesCorey cutler

Cimeio Therapeutics Presents Data for its CD45 Universal Heme ADC at ASH

Cimeio Therapeutics Presents Data for its CD45 Universal Heme ADC at ASH
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United statesSan diegoCorey cutlerSteve edelsonStefan klotterAmerican society of hematologyCimeio therapeutics incStem cell transplantation programHspcs are shielded fromProfessor of medicine at harvard medical schoolDana farber cancer instituteAmerican societyStem cells expressing engineeredNear universal targeted therapyHematologic diseasesAre shielded from