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Weill Cornell Researchers Identify Lymphoma Mutation That Disrupts Critical B-Cell Selection Process

Researchers of the Melnick Lab recently published a study identifying a key mutation that disrupts the B-cell natural selection process during immune response, leading to aggressive diffuse large B-cell lymphoma within the body.

Lymphoma mutation yields super-competitive immune cells

Lymphoma mutation yields super-competitive immune cells
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Mutations may underlie how the most aggressive lymphomas arise and resist therapies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators.

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