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Ribociclib Plus Endocrine Therapy Meets iDFS End Point in HR+ Early Breast Cancer

The combination of ribociclib and endocrine therapy (ET) significantly reduced the risk of disease recurrence vs standard adjuvant ET in patients with hormone receptor–positive/HER2-negative early breast cancer at risk of recurrence.

United statesDennisj slamonShreeram aradhyeTranslational research in oncologyLos angeles jonsson comprehensive cancer centerUniversity of californiaClinical translational researchData monitoring committeeGlobal drug developmentIndependent data monitoring committeeTranslational researchStandardized definitionsEfficacy end pointsBreast cancerEarly breast cancer

NATALEE (TRIO033) Phase III trial demonstrates ribociclib significantly reduces the risk of recurrence for patients with early breast cancer, at interim analysis

NATALEE (TRIO033) Phase III trial demonstrates ribociclib significantly reduces the risk of recurrence for patients with early breast cancer, at interim analysis
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United statesDennisj slamonCatherine marleLos angeles jonsson comprehensive cancer centerTranslational research in oncologyClinical translational researchUniversity of californiaResearch in oncologyTranslational researchExecutive director

Electrolyte pre-loading investigated in horses

Horses were pre-loaded with different quantities of an electrolyte solution to investigate the effects on acid-base balance after exercise.

United statesMichael lindingerAmanda wallerClinical translational researchNutraceutical alliance inc in guelphUniversity of guelphVariables in exercising horsesTranslational researchNationwide childrenNutraceutical alliance incAcid base variablesExercising horsesPre loading oralCreative commons license

Key to new lupus treatment lies in blood: Study

A new study suggests that restoring the balance of a protein in the blood could be a promising treatment option for systemic lupus erythematosus, also known as

United statesFong kok yongWilliam hwangDrug administrationDepartment of haematologyNational cancer centre singaporeDepartment of clinical translational researchDepartment of rheumatologyimmunologySenior researchDepartment rheumatologyimmunologyClinical servicesDeputy groupSingapore general hospitalNature reviews rheumatologyUnited states foodAssociate professor andrea low

Key to new lupus treatment lies in blood: Study

A new study suggests that restoring the balance of a protein in the blood could be a promising treatment option for systemic lupus erythematosus, also known as lupus, an untreatable autoimmune disease.

United statesFong kok yongWilliam hwangDrug administrationDepartment of haematologyDepartment rheumatology immunologyNational cancer centre singaporeDepartment of rheumatology immunologyDepartment of clinical translational researchSenior researchClinical servicesDeputy groupSingapore general hospitalNature reviews rheumatologyUnited states foodAssociate professor andrea low