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Janssen If fatigue is part of your life with relapsing multiple sclerosis (RMS) and it likely is a new drug may provide some relief. JAMA Neurology, ponesimod (marketed under the brand name Ponvory) was found to reduce fatigue significantly better than teriflunomide (Aubagio), another commonly used drug in the treatment of RMS. In addition, the drug was found to surpass teriflunomide in lowering the MS relapse rate in study participants and in reducing the risk of new or enlarging lesions seen on magnetic resonance imaging (MRI) scans. Ponesimod was approved by the U.S. Food and Drug Administration (FDA) in March 2021 for use in adults with various types of RMS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary-progressive MS (SPMS).

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