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Startup banks on immune-system memory to tackle cancer
Loki Therapeutics is advancing research that leverages the immune system s ability to recall childhood vaccinations and direct it against cancer. The company s lead therapy candidate could enter phase 1 clinical trials this year.
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A New York-based startup is advancing what it believes is a novel approach to harnessing the immune system to fight cancer.
Many approaches rely in some way on training blank T-cells to recognize and attack cancer cells. Founded in 2020, Loki Therapeutics is based on research that makes cancer cells look like targets the body already recognizes.
The idea is essentially to “wake up” the immune system and reactivate T-cells that carry the memory of childhood vaccinations against diseases like tetanus, measles and mumps. The strategy reflects the fact that T cells carry the memory of those diseases long after shots are given.