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Blocking Immune Molecule Slows Aggressive Childhood Cancer

Blocking Immune Molecule Slows Aggressive Childhood Cancer
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Marta alonsoIker ausejo mauleonCima solid tumor programPablo ugarte associationCancer center clSpanish association against cancerEuropean research councilCima cancer divisionAdey foundationUniversidad de navarraDiffuse midline glioma

Blocking immune molecule reduces tumor growth, prolongs survival of most aggressive childhood cancer in animal models

Blocking immune molecule reduces tumor growth, prolongs survival of most aggressive childhood cancer in animal models
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Iker ausejo mauleonMarta alonsoCima solid tumor programCima cancer divisionCancer cellUniversidad de navarraDiffuse midline glioma

Blocking TIM-3 checkpoint molecule promotes antitumor immune response in diffuse intrinsic stem glioma

Researchers from Cima and the Clínica Universidad de Navarra, together with the international cooperative group Diffuse Midline Glioma (DMG-ACT), have confirmed that blocking an immune checkpoint molecule reduces the tumor and prolongs survival in animal models of the most aggressive childhood cancer. This research, carried out at the Cancer Center Clínica Universidad de Navarra, shows that inhibition of TIM-3 promotes the immune memory of diffuse intrinsic stem glioma (DIPG) and improves the prognosis of the disease.

Lily ramseyMarta alonsoIker ausejo mauleonCancer center clCima university of navarraEuropean research councilCima solid tumor programSpanish association against cancerAdey foundationPablo ugarte associationCima cancer divisionUniversidad de navarraDiffuse midline gliomaCima universityCima solid tumorImmune response