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Chronic obstructive pulmonary disease (COPD) is one of the most lethal chronic disease worldwide; however, the establishment of reliable in vitro models for exploring the biological mechanisms of COPD remains challenging. Here, we determined the differences in the expression and characteristics of the autophagic protein LC3B in normal and COPD human small airway epithelial cells and found that the nucleus of COPD cells obviously accumulated LC3B. We next established 3D human small airway tissues with distinct disease characteristics by regulating the biological microenvironment, extracellular matrix, and air-liquid interface culture methods. Using this biomimetic model, we found that LC3B affects the differentiation of COPD cells into basal, secretory, mucous, and ciliated cells. Moreover, although chloroquine and ivermectin effectively inhibited the expression of LC3B in the nucleus, chloroquine specifically maintained the performance of LC3B in cytoplasm, thereby contributing to the
Ein 60-jähriger Raser tötet drei Menschen auf der Wasserburger Landstraße. Nun entscheidet das Gericht im Berufungsverfahren über die Haftstrafe. Viele Fragen bleiben offen.
Staatsoper goes Künstlerhaus oe1.orf.at - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from oe1.orf.at Daily Mail and Mail on Sunday newspapers.
70 Jahre Nürnberger Prozess: Der Anfang einer neuen Zeitordnung - Literatur - Kultur tagesspiegel.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagesspiegel.de Daily Mail and Mail on Sunday newspapers.