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Study finds sex differences in astrocyte-mediated synaptic connectivity during brain development During development, brain cells may find different ways to connect with each other based on sex, according to researchers at the Marshall University Joan C. Edwards School of Medicine. The study, recently published in eNeuro, an open access journal for the Society of Neuroscience, showed a significantly more robust synaptogenic response in male-derived cells compared to female-derived cells when exposed to factors secreted from astrocytes, which are non-neuronal cells found throughout the central nervous system. This difference was driven largely by how neurons responded to thrombospondin-2 (TSP2), a protein with cell adhesion properties that is normally secreted by astrocytes. In the study, TSP2 prompted a strong increase in synapses in male neurons while showing no effect on female neurons.

Hanna mazurW christopher risherEmily hendersonJoanc edwards school of medicineSociety of neuroscienceMarshall university joanChristopher risherஅண்ணா மஜுர்டப்ல்யூ கிறிஸ்டோபர் ரைஷர்எமிலி ஹென்டர்சன்சமூகம் ஆஃப் நரம்பியல்மார்ஷல் பல்கலைக்கழகம் ஜோன்கிறிஸ்டோபர் ரைஷர்