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What happens when the brain loses a hub?
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Rare pre- and post-operative recordings show what happens after the brain loses a hub
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Last modified on Tue 25 May 2021 00.08 EDT
A blind man has had his sight partly restored after a form of gene therapy that uses pulses of light to control the activity of nerve cells – the first successful demonstration of so-called optogenetic therapy in humans.
The 58-year-old man, from Brittany in northern France, was said to be “very excited” after regaining the ability to recognise, count, locate and touch different objects with the treated eye while wearing a pair of light-stimulating goggles, having lost his sight after being diagnosed with retinitis pigmentosa almost 40 years ago.
The breakthrough marks an important step towards the more widespread use of optogenetics as a clinical treatment. It involves modifying nerve cells (neurons) so that they fire electrical signals when they’re exposed to certain wavelengths of light, equipping neuroscientists with the power to precisely control neuronal signalling within the brain and elsewhere.