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Izzy Jayasinghe Harnesses Cutting-Edge Microscopy to Image Cells

ABOVE: © STUART ROBINSON Asked what initially drew her to science, Izzy Jayasinghe has a modest answer. “I wasn’t very good at very many other things in school,” she says. “And I had, I guess, a general curiosity.” While in high school in New Zealand, Jayasinghe built a viscoelastic damper, a type of shock absorber used in cars and in buildings in earthquake-prone areas, and tested how various design parameters affected its performance.  The project won an award at a science fair for the city of Auckland, with a prize of a small scholarship to the University of Auckland, where she studied biomedicine beginning in 2003. During her senior year, Jayasinghe worked in the lab of biophysicist Christian Soeller, using a confocal microscope to examine the positions of proteins known as sodium-calcium exchangers in heart cells. Previous research had produced conflicting results on whether these exchangers colocalized with another type of protein known as ryanodine receptors. By

Pioneering new technique could revolutionise super-resolution imaging systems

 E-Mail Scientists have developed a pioneering new technique that could revolutionise the accuracy, precision and clarity of super-resolution imaging systems. A team of scientists, led by Dr Christian Soeller from the University of Exeter s Living Systems Institute, which champions interdisciplinary research and is a hub for new high-resolution measurement techniques, has developed a new way to improve the very fine, molecular imaging of biological samples. The new method builds upon the success of an existing super-resolution imaging technique called DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) - where molecules in a cell are labelled with marker molecules that are attached to single DNA strands.

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