Measuring ctDNA levels before radiotherapy predicted PFS and overall survival, and can help determine the patients most likely to benefit from consolidation radiotherapy vs systemic therapy.
Addition of ravulizumab to BSC did not improve survival or other secondary outcomes.
Safety findings were consistent with the known safety profile of ravulizumab in its
approved indications. Despite the lack of efficacy, the study adds value for future
research into complement therapeutics in critical illnesses by showing that C5 inhibition
can be accomplished in severely ill patients.
Infants born to mothers living in poverty have smaller volumes of gray and white matter across the entire brain. Additionally, babies born to mothers who live in high crime areas showed differences in brain activity to those whose mothers lived in safer areas. Those born to mothers who experienced crime had weaker neural connections between brain areas that control and process emotions. Maternal stress, researchers say, could be a main factor in the differences in neuroanatomy and brain connectivity.