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How the material of the battery electrode affects its performance and lifespan
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N4 Pharma Chengzhong Yu awarded grant to work on patented nuvec® nanoparticle
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IMAGE: (a) cellular uptake, (b) endosomal escape, (c) GSH depletion contributed by tetrasulfide-induced GSH oxidation and zinc-mediated inhibition of GR and GSSG reduction, (d) GAPDH deactivation, (e) increased MMP, (f) mTORC1. view more
Credit: @Science China Press
Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA nanocarriers mainly focus on their physical interaction with mRNA molecules, or protection / delivery of mRNA, such as adjusting physical properties of nanocarriers to control binding with mRNA or cellular uptake. Moreover, effective mRNA delivery in hard-to-transfect APCs remains a challenge. The hard-to-transfect nature in APCs is partly attributed to the suppressed mRNA translation associated with the intrinsic high intracellular glutathione (GSH) level. Thus, tetrasulfide bond bridged DMONs modifie