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N4 Pharma Chengzhong Yu awarded grant to work on patented nuvec® nanoparticle

N4 Pharma Chengzhong Yu awarded grant to work on patented nuvec® nanoparticle
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N4 Pharma expands Professor Yu partnership on grant award

N4 Pharma PLC - Derby, England-based pharmaceutical company focused on developing Nuvec, a delivery system for vaccines and cancer treatments - Says it will be supporting the University of Queensland as part of a recent grant award by the Australian Rese.

Confined growth of ZIF-8 in organosilica nanoparticles to regulate mRNA translation

 E-Mail IMAGE: (a) cellular uptake, (b) endosomal escape, (c) GSH depletion contributed by tetrasulfide-induced GSH oxidation and zinc-mediated inhibition of GR and GSSG reduction, (d) GAPDH deactivation, (e) increased MMP, (f) mTORC1. view more  Credit: @Science China Press Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA nanocarriers mainly focus on their physical interaction with mRNA molecules, or protection / delivery of mRNA, such as adjusting physical properties of nanocarriers to control binding with mRNA or cellular uptake. Moreover, effective mRNA delivery in hard-to-transfect APCs remains a challenge. The hard-to-transfect nature in APCs is partly attributed to the suppressed mRNA translation associated with the intrinsic high intracellular glutathione (GSH) level. Thus, tetrasulfide bond bridged DMONs modifie

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