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Breakthrough epigenetic study can improve the power to predict disease risk

The researchers hope their approach will have transformative effects in the field of epigenetic epidemiology.

United statesBaylor college of medicineEleonora laritskySandral grimmCristian coarfaMarias bakerJosephl wiemelsChathuraj gunasekaraYumei liRoberta waterlandHarry mackayC anthony scottRui chenShaobo liDarryl lejaPrecision environmental health at baylor

Scientists propose obesity is neurodevelopmental disorder

Scientists propose obesity is neurodevelopmental disorder
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Baylor college of medicineUnited statesRobert waterlandCristian coarfaChathuraj gunasekaraDollada srisaiYumei liHarry mackayHari krishna yalamanchiliRui chenChildren nutrition research center at baylorDan duncan neurological research instituteVanderbilt universityResearchers at baylor college of medicineBaylor danl duncan comprehensive cancer centerBaylor college

Obesity May Be a Neurodevelopmental Disorder - Neuroscience News

Obesity is, in part, determined by epigenetic development in the arcuate nucleus of the hypothalamus. Findings suggest developmental epigenetics plays a significant role in both environmental and genetic influences on obesity risk.

Baylor college of medicineUnited statesRobert waterlandCristian coarfaChathuraj gunasekaraDollada srisaiYumei liHarry mackayHari krishna yalamanchiliRui chenChildren nutrition research center at baylorDan duncan neurological research instituteVanderbilt universityResearchers at baylor college of medicineBaylor danl duncan comprehensive cancer centerBaylor college

Model May Identify Schizophrenia Cases by DNA Methylation in Blood

Model May Identify Schizophrenia Cases by DNA Methylation in Blood
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United statesBaylor college of medicineChathuraj gunasekaraHealthday newsBaylor collegeHuman methylationஒன்றுபட்டது மாநிலங்களில்பேலர் கல்லூரி ஆஃப் மருந்துபேலர் கல்லூரி

Innovative strategy for early diagnosis of schizophrenia

Innovative strategy for early diagnosis of schizophrenia An innovative strategy that analyzes a region of the genome offers the possibility of early diagnosis of schizophrenia, reports a team led by researchers at Baylor College of Medicine. The strategy applied a machine learning algorithm called SPLS-DA to analyze specific regions of the human genome called CoRSIVs, hoping to reveal epigenetic markers for the condition. In DNA from blood samples, the team identified epigenetic markers, a profile of methyl chemical groups in the DNA, that differ between people diagnosed with schizophrenia and people without the disease and developed a model that would assess an individual s probability of having the condition. Testing the model on an independent dataset revealed that it can identify schizophrenia patients with 80% accuracy. The study appears in the journal

Roberta waterlandChathuraj gunasekaraEmily hendersonChildren nutrition research center at baylorBaylor college of medicineBaylor collegeNutrition research centerரோபர்ட்டா நீர்நிலம்எமிலி ஹென்டர்சன்குழந்தைகள் ஊட்டச்சத்து ஆராய்ச்சி மையம் இல் பேலர்பேலர் கல்லூரி ஆஃப் மருந்துபேலர் கல்லூரிஊட்டச்சத்து ஆராய்ச்சி மையம்