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The final results of a landmark study published in The Lancet Infectious Diseases confirm that the benefits of combining the RTS,S/AS01E (RTS,S) malaria vaccine with antimalarial drugs in settings of highly seasonal malaria transmission continue over five years. The vaccine-drug combination reduced clinical malaria episodes, including cases of severe malaria, and deaths from malaria in young children by nearly two-thirds compared with either RTS,S vaccination or seasonal malaria chemoprevention (SMC) alone.
In a sub-study nested under the MISAME-III trial, an individually randomised controlled efficacy trial in rural Burkina Faso, Carl Lachat and colleagues investigate the effect of prenatal micronutrient-fortified balanced energy-protein supplementation on body composition of mothers and their newborns.
World Malaria Day: Invest, innovate, implement Maternal Immunisation: Prevent, protect, immunise Vaccinating women in pregnancy has emerged as a promising tool to protect women against infectious diseases and tackle infant morbidity and mortality worldwide. LSHTM Vaccine Centre World Immunisation Week activities will showcase the development of new maternal vaccines and provide the opportunity to discuss other vaccines with potential positive health outcomes.
Carl Lachat and colleagues report a a 2×2 factorial individually randomized controlled trial conducted in rural Burkina Faso which investigates the impact of fortified balanced energy-protein supplementation during pregnancy and lactation on infant growth.