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In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle Children's Research Institute and Sanaria Inc. describe the development of a whole malaria parasite vaccine strain that infects the liver, develops to the late liver stage, and then gets completely stuck and cannot burst out of the liver to cause symptomatic blood infection.

Burkina fasoHardik patelB kim lee simPeter kremsnerStephenl hoffmanDebashree goswamiCentre de recherchesUniversity of washingtonSeattle children research instituteAshley vaughan at seattle children research instituteDepartment of pediatricsStefan kappe at seattle children research instituteInstitute for tropical medicineSanaria incSeattle childrenResearch institute