Nuclear Medicine Cures Deadly Ovarian Cancer in Lab Test miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
This groundbreaking nine-year study used advanced mass spectrometry to analyze lipid profiles in human plasma, revealing dynamic changes tied to aging, insulin resistance, and viral infections. The findings suggest that specific lipid subclasses are crucial indicators and potential targets for treatment in human health and various diseases.
DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair factors, Polθ function is activated in mitosis upon phosphorylation by Polo-like kinase 1 (PLK1). Phosphorylated Polθ is recruited by a direct interaction with the BRCA1 C-terminal domains of TOPBP1 to mitotic DSBs, where it mediates joining of broken DNA ends. Loss of Polθ leads to defective repair of mitotic DSBs, resulting in a loss of genome integrity. This is further exacerbated in
MULTIPLE FACULTY POSITIONS AVAILABLE job in Newark, New Jersey (US) with Rutgers Biomedical and Health Sciences NJMS-Center for Cell Signaling. Apply Today.
MANCHESTER-BY-THE-SEA — Town officials and Planning Board members have a full to-do list to tackle in the coming months, and they’re looking to hire a full-time land use director or