8 Cytokines, including Il-1β, TNF-α, and PEG
2 and VEGF, have been certified to play an important role in DED, and by inhibiting expression of those cytokines, symptoms of DED could be significantly alleviated.
35–39 Traditional anti-inflammatory agents like corticosteroids would result in disastrous incidence if inappropriately applied, including intraocular hypertension and cataract,
10 which narrows its use in DED therapy. Therefore, an effective anti-inflammation agent with less impact on intraocular pressure is worthy of exploration. Tet, a plant alkaloid isolated from a traditional Chinese herb,
11 is initially used as an anti-inflammation agent to treat rheumatoid arthritis. It has been demonstrated that Tet could suppress the release of IL-1β, TNF-α, VEGF and PEG
Otto Bremer Trust awards 190 grants totaling $11.4 million
Times Report
Crookston Times
The Otto Bremer Trust has awarded $11,473,300 in grants and program-related investments to 190 organizations in Minnesota, Montana, North Dakota, and Wisconsin, as part of its most recent grantmaking cycle.
Following is a full list of grants awarded in the Red River Region, as well as selected grants in northern Minnesota closest to Crookston.
Red River Region
CCRI, Inc., Moorhead, MN, $60,000. To provide mental health and in-home family support to people with disabilities in Clay County.
Community Health Service Inc., Moorhead, MN, $100,000. For general operations to improve awareness of and targeted access to affordable healthcare for low-income individuals