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AstraZeneca antibody treatment may offer post-COVID-19 exposure protection, researchers say

If effective, this treatment could protect vulnerable populations who haven t yet been vaccinated – or people who can t get inoculated because of health risks, scientists say. It also might help prevent large outbreaks in communities.  The University College London Hospitals NHS Trust in the United Kingdom is conducting a randomized, controlled trial to determine whether antibody donations are an effective COVID-19 treatment.  Volunteers who are exposed to a person with COVID-19 are given an injection of two different antibodies donated from people who are COVID-19 positive. Ten people enrolled in the study already have been given the experimental antibody injection. The researchers expect to recruit a total of 1,000 volunteers.

New antibody therapy that may prompt immunity to COVID-19 goes into trials

The study is led by UCLH virologist Catherine Houlihan, the director of UCL’s Infection and Immunity department. Antibodies, proteins created by an immune response, hunt for foreign intruders, like viruses, in the body to eliminate them. The prevailing theory for antibody-based treatments is that if the body can preemptively have antibodies that recognize the virus, it can react better if infected. The LAAB is composed of monoclonal antibodies, which are artificially made and administered in an effort to strengthen the immune system.  “We know that this antibody combination can neutralise the virus, so we hope to find that giving this treatment via injection can lead to immediate protection against the development of Covid-19 in people who have been exposed – when it would be too late to offer a vaccine,” Houlihan said.

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