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Synthesis of potent antibiotic follows unusual chemical pathway

 E-Mail IMAGE: The synthesis of the potent antibiotic thiostrepton uses a radical SAM protein TsrM, whose crystal structure is shown at left while bound to an iron-sulfur cluster and cobalamin. New images. view more  Credit: Booker Lab, Penn State UNIVERSITY PARK, Pa.  Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic s synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. The antibiotic thiostrepton is very potent against Gram-positive pathogens and can even target certain breast cancer cells in culture, said Squire Booker, a biochemist at Penn State and investigator with the Howard Hughes Medical Institute. While it has been used topically in veterinary medicine, so far it has been ineffective in humans because it is poorly absorbed. We studied

Mass residents receiving SNAP benefits will get boost from stimulus bill Will it be enough?

A young boy waited while his family gathers food at the Brazilian Workers Center food pantry in Allston.Suzanne Kreiter/Globe staff Nearly a million Massachusetts residents who receive federal food assistance will get more money to spend on groceries starting in early February, welcome relief in the midst of an increasingly urgent hunger crisis. The federal stimulus package passed last month by Congress increased Supplemental Nutrition Assistance Program benefits by 15 percent across the country from January through June. Those benefits, which amount to an additional $27 per person per month, will make a big difference, though they remain temporary and are calculated using low costs for food, especially for a high-cost state like Massachusetts, anti-hunger advocates said.

USDA Cuts Back On Hunger Relief Shipments To Massachusetts

USDA Cuts Back On Hunger Relief Shipments To Massachusetts Volunteers pass out fresh vegetables for a Thanksgiving meal at the Alameda Food Bank in Alameda, Calif., in this 2009 file photo. Boston Globe/Boston Globe via Getty Images A change in vendors used by the U.S. Department of Agriculture to supply badly needed food to local hunger relief organizations has severely cut back on its deliveries to the state, members of the Massachusetts congressional delegation said Tuesday. “You can t get enough food out there right now,” said Sasha Purpura, of the Cambridge-based Food for Free Committee. “And that s why these boxes were so important, because they allowed for safe distribution of food in organizations that are under-resourced and don t have, you know, huge facilities and resources.

As COVID pandemic changes the face of hunger, food banks across Massachusetts see double-digit increases in demand

As COVID pandemic changes the face of hunger, food banks across Massachusetts see double-digit increases in demand Updated Jan 05, 2021; Posted Dec 12, 2020 Andrea Allen-Glenn, food coordinator for the Emergency Food Assistance Program at Martin Luther King, Jr. Family Services in Springfield. (Hoan Leon Nguyen / The Republican) Facebook Share Correction: This story has been updated to reflect that In the last 12 months the Food Bank has provided the equivalent of 12.4 million meals in all four Western Massachusetts counties. SPRINGFIELD For more than 20 years, Andrea Allen-Glenn has helped people in need have one less thing to worry about each week. As the food coordinator for the Emergency Food Assistance Program at Martin Luther King, Jr. Family Services on Rutland Street, Allen-Glenn connects people who need food with fresh produce, meat and other items.

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