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Does Radiation TX for NSCLC Set the Stage for Later Heart Disease?

P=0.02), the authors added. “Radiation exposure of arterial vessels alters the natural history of coronary artery disease by inducing inflammation that subsequently triggers accelerated progression if the disease,” Atkins and colleagues explained and added,”Our study suggests that LAD coronary artery V15 Gy greater than or equal to 10% is an independent factor associated with MACE and all-cause mortality in patients with NSCLC.” The analysis included patients who were treated with 3-D conformal radiotherapy or intensity-modulated radiotherapy techniques between December 2001 and January 2014. The median age was 65 years (interquartile range, (IQR), 57-73 years) and almost two-thirds of patients at 64.1% were at high CHD risk according to Framingham criteria. The median follow-up was 20.4 months (IQR, 8.2-44.6 months) and 47.8 months (IQR, 31.6-75.4) months in patients who were still alive at the time of study analysis.

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