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New RNA-based Therapy Combats Melanoma in Mouse Models

Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells which play a key role in immune response that eradicated tumors and prevented their recurrence in mouse models of melanoma.

United statesOhio state universityEast harlemNew yorkBrian brownYizhou dongBinbin deng ohio state universityYonger xue ohio state universityNational instituteIcahn school of medicine at mount sinaiShi du ohio state universityIcahn genomics instituteMerck coDavidw mccomb ohio state universityProfessor of oncological sciencesJingyue yan ohio state university

Orionis Biosciences Announces First Patient Dosed in Phase 1 Clinical Trial of ORB-011 in Patients with Advanced Solid Tumors

Orionis Biosciences Announces First Patient Dosed in Phase 1 Clinical Trial of ORB-011 in Patients with Advanced Solid Tumors
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New yorkUnited statesRheinland pfalzTony fadellOrionis biosciencesOlivia durrNikolai kleyOrionisa kineHonor health research institute in scottsdaleMd anderson cancer centerDpod divisionBuild collectiveOrionis boardChief executive officerNew york times best sellerUnorthodox guide

A Look at Novel Immune Therapies for Kidney Cancer

Researchers continue to investigate novel immunotherapy drugs for the treatment of renal cell carcinoma.

United statesMichaelb atkinsKaty beckermannEric jonaschVivek narayanInternational kidney cancer symposiumHospital of the university pennsylvaniaNovel therapy developmentKidney cancer symposiumImmunity cycleCancer immunity cycleKidney cancer

Cancer Immunity Cycle Could Inform Development of Novel Immune Therapies in RCC

Further understanding of the cancer immunity cycle could drive the development of novel immune therapies for patients with renal cell carcinoma.

United statesMichaelb atkinsVivek narayanEric jonaschKaty beckermannInternational kidney cancer symposiumHospital of the university pennsylvaniaNovel therapy developmentKidney cancer symposiumImmunity cycleCancer immunity cycleImmune therapiesEarly phase clinical developmentNorth americaConventional immune checkpoint inhibitionRenal cell carcinoma

RNA therapy activates dendritic cells to combat melanoma

The RNA-based strategy activated dendritic cells that eradicated tumours and prevented their recurrence in mouse models of melanoma.

Brian brownYizhou dongIcahn genomics instituteJennifer lipschultz precision immunology instituteIcahn school of medicine at mount sinaiIcahn schoolMount sinaiNature nanotechnologyProfessor yizhou dongAssociate directorJennifer lipschultz precision immunologyDendritic cellsNature nanotechnologyCancer immunity cycle