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Artificial intelligence developed to identify cancer mutations

Artificial intelligence developed to identify cancer mutations Asia News Network (ANN) is the leading regional alliance of news titles striving to bring the region closer, through an active sharing of editorial content on happenings in the region.

United statesKiran krishnamachariAnders skanderupAgency for scienceVariant network varnetLaboratory of computational cancer genomicsNational university hospital singaporeGenome institute of singaporeNational cancer centre singaporeResearcha starVariant networkGenome instituteComputational cancerNature communicationsStar computingInformation science

NCI funds study to investigate the underlying cellular mechanisms that drive ER+ breast cancer

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

United statesSanford burnham prebysSvasti haricharanDanielle ellisNational cancer instituteEpigenetics programCancer genomeBreast cancerDna damage

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Clinical proteomic tumor analysis consortiumKyoto encyclopediaCancer genome

Reprogramming tumour-associated macrophages to outcompete cancer cells

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate unfit cells in favour of their more robust neighbours1,2. This mechanism has the potential to be maladapted, promoting the selection of aggressive cancer cells3–6. Tumours are metabolically active and are populated by stroma cells7,8, but how environmental factors affect cancer cell competition remains largely unknown. Here we show that tumour-associated macrophages (TAMs) can be dietarily or genetically reprogrammed to outcompete MYC-overexpressing cancer cells. In a mouse model of breast cancer, MYC overexpression resulted in an mTORC1-dependent ‘winner’ cancer cell state. A low-protein diet inhibited mTORC1 signalling in cancer cells and reduced tumour growth, owing unexpectedly to activation of the transcription factors TFEB and TFE3 and mTORC1 in TAMs. Diet-derived cytosolic amino acids are sensed by Rag GTPases through the GTPase-activating proteins GATOR1 and FLCN

Cell bioCancer biolCell biolDrosophila mycCancer genomeCell systNot ragbNatl cancer instBio cancer genomics portal

Theoretical Analysis of Sequencing Bioinformatics Algorithms and Beyond

Theoretical Analysis of Sequencing Bioinformatics Algorithms and Beyond
acm.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from acm.org Daily Mail and Mail on Sunday newspapers.

Al qahirahNew yorkUnited statesUnited kingdomSchloss dagstuhlPaul medvedevMonte carloTitus brownNational instituteObama precision medicine initiativeNucleic acids researchCm assemblyDepartment of computer scienceAssociation for computing machineryCambridge universityUniversity park