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Day One Announces Positive Initial Data from Pivotal FIREFLY-1 Trial of Tovorafenib (DAY101) in Relapsed Pediatric Low-Grade Glioma - Press Release

Data show an overall response rate (ORR) of 64% and clinical benefit rate (CBR) of 91% in the first 22 evaluable patients treated with monotherapy tov

United statesDan budwickSamuel blackmanHans vitzthumRoger packerEuropean commissionDrug administrationBrain tumor instituteOncology consortiumGerman cancer research centerExchange commissionHopp children cancer center heidelberg kiChildren national hospitalDevelopment of tovorafenibDay one biopharmaceuticalsPacific pediatric neuro oncology consortium

Day One Announces Positive Initial Data from Pivotal FIREFLY-1 Trial of Tovorafenib (DAY101) in Relapsed Pediatric Low-Grade Glioma

Day One Announces Positive Initial Data from Pivotal FIREFLY-1 Trial of Tovorafenib (DAY101) in Relapsed Pediatric Low-Grade Glioma
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United statesDan budwickSamuel blackmanHans vitzthumRoger packerEuropean commissionDrug administrationBrain tumor instituteOncology consortiumGerman cancer research centerExchange commissionHopp children cancer center heidelberg kiChildren national hospitalDevelopment of tovorafenibDay one biopharmaceuticalsPacific pediatric neuro oncology consortium

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.

Baden wübergSina krethAndres florezFrank westermannHamed alborziniaAndreas trumppEmily hendersonHopp children cancer center heidelberg kiUniversity of heidelberg uniUniversity of heidelbergHeidelberg university hospitalGerman cancer research centerHopp childrenCancer center heidelbergAmino acidAdrenal gland

The Inaugural WHO Classification of Childhood Tumors Will Provide a Unified, Updated Resource for the Diagnosis of Pediatric Cancers

Resource reflects transition from a mostly microscopy-driven to a molecularly driven classification system.

United statesUnited kingdomStefanm pfisterBambino gesuRita alaggioUniversity of pittsburgh school medicineGerman childhood cancer foundationGerman cancer research centerHopp children cancer center heidelberg kiUk national institute of health researchPediatric brain tumor foundationInternational agency for research on cancerDepartment of laboratoriesMarjoriek harmer endowment for researchBrain tumour charityGerman research foundation deutsche forschungsgemeinschaft

Inaugural WHO classification of childhood tumors will provide unified, updated resource for diagnosis of pediatric cancers

Bottom Line: This review article summarizes the first classification of pediatric cancers soon to be published by the International Agency for

United statesUnited kingdomStefanm pfisterRita alaggioUniversity of pittsburgh school medicineGerman childhood cancer foundationGerman cancer research centerHopp children cancer center heidelberg kiUk national institute of health researchPediatric brain tumor foundationInternational agency for research on cancerDepartment of laboratoriesMarjoriek harmer endowment for researchBrain tumour charityGerman research foundation deutsche forschungsgemeinschaftGerman federal ministry of education