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Caloric restriction is the gold standard life extension strategy, validated over thousands of experiments in many animal species. How can we reconcile this with consistent findings that people who are slightly overweight live longer than normal or underweight folks?
The one fact that everyone in the field of aging agrees on is that animals fed less live longer. This is the result that got me interested in the field 25 years ago, and it is still the most robust finding in the field, verified in dozens of species from yeast cells to Rhesus monkeys.
Are humans different from all other animals?