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Patients report no quality-of-life issues with adjuvant regimen for high-risk liver cancer

CHICAGO — Individuals with high-risk hepatocellular carcinoma undergoing curative-intent procedures did not experience clinically meaningful deterioration in quality of life or function after adjuvant therapy, phase 3 study results showed.Patient-reported outcomes from the randomized IMbrave050 trial presented at ASCO Annual Meeting suggest that an adjuvant regimen of atezolizumab plus

Cross-border partnership takes on huge survival gap among children with leukemia

A partnership between health care systems along the U.S.-Mexico border led to clinically meaningful improvement in survival outcomes among children with acute lymphoblastic leukemia, study results showed. The analysis of the cancer treatment training and access initiative — scheduled for presentation at ASCO Annual Meeting — revealed a significant increase in 5-year OS among children

Luspatercept a paradigm shift in transfusion-dependent myelodysplastic syndrome

Treatment with luspatercept vs. epoetin alfa nearly doubled the number of patients with lower-risk myelodysplastic syndrome who no longer required red blood cell transfusions for anemia, results of the phase 3 COMMANDS trial showed.The findings, scheduled for presentation at ASCO Annual Meeting, showed luspatercept (Reblozyl; Celgene, Bristol Myers Squibb) — an erythroid maturation agent

Gene therapy a potential functional cure for sickle cell disease, beta thalassemia

Treatment with exagamglogene autotemcel conferred clinically meaningful increases in fetal hemoglobin and total hemoglobin levels among patients with beta-thalassemia and sickle cell disease, results of two pivotal studies showed. The latest follow-up data from the CLIMB THAL-111 and CLIMB-SCD-121 trials — presented at American Society for Gene & Cell Therapy Annual Meeting —

Novel leukemia treatment signals new era in CAR T-cell therapy

An investigational chimeric antigen receptor T-cell therapy demonstrated successful expansion and antitumor targeting among younger patients with advanced acute myeloid leukemia, results of the phase 1 PLAT-08 trial showed. The findings — presented at American Society for Gene & Cell Therapy Annual Meeting — demonstrated the feasibility and safety of pharmacologically controlled

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