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KIBRA restores tau-driven damage in Alzheimer s disease

It is well known that protein tau forms aggregates in the brain in neurodegenerative diseases such as Alzheimer’s disease (AD) that are also known as tauopathies. Accumulation of protein tau in the brain leads to the cell toxicity and promotes the loss of synaptic plasticity, which in turn causes memory loss. As reported on Feb. 1, 2024, in The Journal of Clinical Investigation, assistant professor Tara Tracy and her research team from the Buck Institute for Research on Aging have discovered a protein in the brain that could restore this damage induced by protein tau.

Alzheimer s Tau Tolerated Better When Synapse Repair Protein Present

Alzheimer s Tau Tolerated Better When Synapse Repair Protein Present
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Buck scientists discover a potential way to r

<p>While newly approved drugs for Alzheimer&rsquo;s show some promise for slowing the memory-robbing disease, the current treatments fall far short of being effective at regaining memory. What is needed are more treatment options targeted to restore memory, said <a href="https://www.buckinstitute.org/lab/tracy-lab/">Buck Assistant Professor Tara Tracy, PhD</a>, the senior author of a study that proposes an alternate strategy for reversing the memory problems that accompany Alzheimer&rsquo;s disease and related dementias.</p>

Brain and kidney protein could restore memories taken by Alzheimer s disease

Brain and kidney protein could restore memories taken by Alzheimer s disease
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