Psychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly af
This story may contain details that are disturbing.If you or someone you know is having thoughts of suicide, please contact the National Suicide Prevention Lifeline at 988.In January 2022, Robert and Rose Bronstein's 15-year-old son died by suicide after The Latin School of Chicago allegedly ignored the teenager's complaints about bullying on social media from
Two parents say The Latin School of Chicago failed to report their 15-year-old son's concerns about cyberbullying before he died by suicide in January 2022.
In January 2022, Robert and Rose Bronstein's 15-year-old son died by suicide after The Latin School of Chicago allegedly ignored the teenager's complaints about bullying on social media from his peers.
A longitudinal study in Finland shows that male school bullies and male victims of bullying are more likely to commit violent offences as adults. This association was much less clear in females. The study was published in the European Child & Adolescent Psychiatry. .