The crash was reported about 12:11 p.m.
MHP Public Information Officer Staff Sgt. Derrick M. Beckom said Stella L. Wofford, 50, of Houston was southbound when her red Ford Free car struck the rear of a southbound 2002 Cadillac driven by Brittany L. Williams, 38, of Pheba.
Both cars were in motion at the time of the crash.
The Cadillac ran off the right side of the road and overturned, ejecting passenger Charles Lushon Wofford, 54, of Houston. Wofford was not wearing a seat belt at the time of the crash, Staff Sgt. Beckom said.
Chickasaw County Coroner Michael Fowler pronounced Wofford dead at the scene.