A form of inflammatory cell death called panoptosis triggers the storm of cytokines, or inflammatory proteins, that causes critical illness in COVID-19, researchers say. During inflammatory cell death, cells spew out their contents instead of neatly packaging them away as happens during routine cell death, Thirumala-Devi Kanneganti of St. Jude Children s Research Hospital told Reuters. Neighboring cells see the cytokines released and the other unexpected debris as a sign of danger, and they can respond by secreting more cytokines, allowing the cytokine storm to build.
Her team identified a synergy between two cytokines, TNF-alpha and IFN-gamma, as the cause of panoptosis in COVID-19. Mice given TNF-alpha and IFN-gamma developed the symptoms and organ damage of COVID-19 and died rapidly, Kanneganti said.
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<div class="at-above-post addthis tool" data-url="https://www.metro.us/uk-variant-linked-to/"></div>(This December 28 story corrects first item to indicate that higher viral loads were in swab samples, not in blood) (Reuters) – The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus. UK coronavirus […]<! AddThis Advanced Settings above via filter on get the excerpt ><! AddThis Advanced Settings below via filter on get the excerpt ><! AddThis Advanced Settings generic via filter on get the excerpt ><! AddThis Share Buttons above via filter on get the excerpt ><! AddThis Share Buttons below via filter on get the excerpt ><div class="at-below-post addthis tool" data-url="https://www.metro.us/uk-variant-linked-to/"></div><! AddThis Share Buttons
December 29, 2020 | 12:53 pm Font Size
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The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.
UK coronavirus variant associated with higher viral loads
The highly infectious COVID-19 coronavirus variant that has been circulating in Britain is linked to higher loads of the virus in the blood, according to a research report published on medRxiv on Sunday ahead of peer review. Around 35% of patients infected by the variant form had very high levels of the virus in their samples, compared to 10% of patients without the variant, study leader Michael Kidd of Public Health England and Birmingham University told Reuters. Higher viral loads have been linked with worse COVID-19 outcomes. The tests were conducted at the Birmingham Turnkey Lab. Kidd said additional study was needed to confirm or refute the findings. If confirmed, he hopes scie
Neanderthal Gene Protects Against COVID-19 medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.