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Scientists have long known that the cells’ ‘protein destruction machine’, the proteasome, plays a crucial role in protein clearance within the brain. However, a new study published in Science has revealed that its essential component, the 19s regulatory particle, has an independent "moonlighting" role at synapses, and thus might offer new opportunities in the diagnosis and treatment of a range of neurological disorders.

DenmarkDanishErin schumanChao sunLundbeck foundationMethod of researchGroup leaderMax planck institute for brain researchDanish research institute for translational neuroscienceAssociate professorBrain prizeMax planck instituteDanish research instituteTranslational neuroscienceFree proteasomal regulatoryParticles regulate neuronal synapses independent