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Lilly and Incyte s baricitinib reduced deaths among patients with COVID-19 receiving invasive mechanical ventilation
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FDA broadens existing emergency use of Lilly and Incyte s baricitinib in patients hospitalized with COVID-19 requiring oxygen
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Coronavirus Disease Weekly News 18April 2021
The news posted last week for the coronavirus 2019-nCoV (aka SARS-CoV-2), which produces COVID-19 disease, has been surveyed and some important articles are summarized here. The articles are more or less organized with general virus news and anecdotes first, then stories from around the US, followed by an increased number of items from other countries around the globe. Economic news related to COVID-19 is found here.
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Summary:
New US cases of the coronavirus continued to inch a bit higher this week, while deaths attributed to the virus continued to fall. New Covid infections during the week ending April 17th were 2.2% higher than during the week ending April 10th, and up 26.5% from the 7 days ending March 16th (a six month low), but still down 72.6% from the early January peak. US Covid deaths were down 2.5% from the prior week, and down 78.7%
Search jobs 09-Apr-2021 Lilly and Incyte announce results from the Phase 3 COV-BARRIER study of baricitinib in hospitalized COVID-19 patients
- Randomized, double-blind, placebo-controlled study of 1,525 patients did not meet statistical significance on primary endpoint (progression to non-invasive ventilation or invasive mechanical ventilation or death)
- Data showed 38% reduction in mortality by Day 28 (nominal p-value=0.0018) in patients treated with baricitinib in addition to standard of care, including corticosteroids and remdesivir
Eli Lilly and Company (NYSE: LLY) and Incyte (NASDAQ:INCY) announced today results of COV-BARRIER, a Phase 3 study evaluating baricitinib 4 mg once daily plus standard of care (SoC) versus placebo plus SoC. The trial did not meet statistical significance on the primary endpoint, which was defined as a difference in the proportion of participants progressing to the first occurrence of non-invasiv
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INDIANAPOLIS (dpa-AFX) - Eli Lilly and Company (LLY) and Incyte (INCY) on Thursday said their late-stage study of baricitinib in hospitalized Covid-19 patients did not achieve the main goal.
The phase III study dubbed Cov-Barrier of baricitinib plus standard of care (SoC) versus placebo plus SoC did not meet statistical significance on the primary endpoint. The main goal was defined as the difference in the proportion of participants progressing to the first occurrence of non-invasive ventilation including high flow oxygen or invasive mechanical ventilation including extracorporeal membrane oxygenation (ECMO) or death by Day 28.
The frequency of adverse events and serious adverse events were generally similar in the baricitinib and placebo groups, Eli Lilly said.
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