by Tyler Durden
Wednesday, May 12, 2021 - 04:15 AM
The best way to decrease the risk of Alzheimer s disease could be a Mediterranean diet that is rich in fish, vegetables, and olive oil, according to a new study.
The research, titled Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age, was published in the online issue of Neurology, the medical journal of the American Academy of Neurology, and found a Mediterranean rich diet may protect the brain from protein build-up and shrinkage that can lead to the debilitating neurological disease.
The study examines abnormal proteins called amyloid and tau. The amyloid-beta precursor protein plays a vital role in neural growth and repair. However, later in life, a corrupted version can destroy nerve cells, leading to memory loss, while tau is a protein that forms into a tangle. Both are found in the brains of people with Alzheimer s disease but may also be found in the brains of older adults with heal
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People who followed a Mediterranean-style diet closely had less amyloid and tau pathology, increased brain volume in regions vulnerable to Alzheimer s disease, and better memory performance, a cross-sectional analysis in Germany showed.
Higher adherence to a Mediterranean type of diet was linked to larger mediotemporal gray matter volume, better memory scores, and lower pathological levels of biomarkers for amyloid plaques and tau tangles, reported Tommaso Ballarini, PhD, of the German Center for Neurodegenerative Diseases (DZNE) in Bonn, and co-authors.
Mediotemporal volume mediated the association between diet and memory. Diet adherence favorably moderated links between amyloid beta (Aβ42/40 ratio), phosphorylated tau 181 (p-tau181), and mediotemporal atrophy, they wrote in
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In Alzheimer s disease, neurons in the brain die. Largely responsible for the death of neurons are certain protein deposits in the brains of affected individuals: So-called beta-amyloid proteins, which form clumps (plaques) between neurons, and tau proteins, which stick together the inside of neurons. The causes of these deposits are as yet unclear. In addition, a rapidly progressive atrophy, i.e. a shrinking of the brain volume, can be observed in affected persons. Alzheimer s symptoms such as memory loss, disorientation, agitation and challenging behavior are the consequences.
Scientists at the DZNE led by Prof. Michael Wagner, head of a research group at the DZNE and senior psychologist at the memory clinic of the University Hospital Bonn, have now found in a study that a regular Mediterranean-like dietary pattern with relatively more intake of vegetables, legumes, fruit, cereals, fish and monounsaturated fatty acids, such as from olive oil, may protect against protein
Data from Lilly at International Conference on Alzheimer s & Parkinson Diseases 2021™ (AD/PD™ 2021) to Showcase Clinical Advances in Alzheimer s Disease Research
Highlights include results from the Phase 2 Trailblazer-ALZ study for donanemab
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INDIANAPOLIS, March 9, 2021 /PRNewswire/ New data from 10 studies will be presented by Eli Lilly and Company (NYSE: LLY) at the upcoming virtual International Conference on Alzheimer s & Parkinson Diseases
™ 2021 (AD/PD
™ 2021), March 9-14, 2021. Lilly will present detailed results of the TRAILBLAZER-ALZ phase 2 study, which showed that donanemab treatment resulted in significant slowing of decline in a composite measure of cognition and daily function in people with early symptomatic Alzheimer s disease (AD) compared to placebo. Additional data highlight Lilly s AD program focused on developing both disease-modifying therapies that slow clinical progression by targeting t
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