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email article Optogenetic therapy restored partial vision in a blind 58-year-old man diagnosed with retinitis pigmentosa almost 40 years ago, according to a case report from the ongoing PIONEER study. In this open-label phase I/IIa study, intraocular injection of an optogenetic sensor-expressing gene therapy vector combined with use of light-stimulating goggles was found to partially restore visual function in a patient with visual acuity of only light perception, reported José-Alain Sahel, MD, of the University of Pittsburgh, and colleagues in Retinitis pigmentosa is an inherited neurodegenerative disease that breaks down light-receptive cells in the retina and can lead to complete blindness. More than 2 million people worldwide are affected by this progressive disease. There is no approved treatment, except for a gene replacement therapy that works only in an early-onset form of the disease caused by a mutation in the

Botond roskaInstitute of molecularUniversity of pittsburghAlain sahelClinical ophthalmology baselRetinitis pigmentosaIntraocular inflammationநிறுவனம் ஆஃப் மூலக்கூறுபல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க்அலன் சஹேல்மருத்துவ கண் மருத்துவம் பேசல்கிள la கோமா