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Researchers identify several novel SARS-CoV-2 inhibitors
Researchers in London, UK, have identified several compounds with SARS-CoV-2 inhibiting properties, that potentially may be developed into antiviral solutions in the future.
A pre-print version of the research paper is available to read in full on the
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate globally, despite the steady rollout of vaccines. More than 150,000 infectious cases are diagnosed daily across the world. Since the virus was first detected in December 2019, over 135 million cases of COVID-19 have been confirmed, with over 2.9 million deaths worldwide.
Most worrisome is the rapid appearance of multiple variants of concern (VOCs), many of which appear to have some degree of immunity to the vaccines. Thus, developing a novel antiviral compound that can target key sites of the virus to disable it is of great importance. The development of novel drug and vaccine therapies can ta
Colchicine may have therapeutic potential against COVID-19
Against the sheer scale of morbidity and death due to the ongoing coronavirus disease 2019 (COVID-19) pandemic, the urgency of identifying drugs and other measures that reduce these adverse outcomes is enormous.
A new study – involving an international team of researchers from Canada, the U.S. and Brazil – describes the results of colchicine in mitigating the inflammatory storm associated with COVID-19, illustrating the drug s potential for preventing a percentage of severe and critical cases.
medRxiv preprint server.
The role of inflammation in COVID-19
Evidence is building up that the so-called “cytokine storm” is key in triggering severe or critical COVID-19 disease by the associated severe and systemic inflammatory damage caused by high levels of circulating cytokines on multiple organs. Drugs that prevent or regulate inflammation could thus be helpful in reducing the risk of poor outcomes in this condition.