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Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR)

Objective To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. Design Two parallel group multicentre phase III randomised placebo controlled trial. Setting 106 general practices in four UK sites; Bristol, Exeter, Hull, and Keele/North Staffs, August 2013 to October 2015. Participants 480 adults aged 18 or more years who scored 14 or more on the Beck depression inventory, second revision, fulfilled ICD-10 (international classification of diseases, 10th revision) criteria for depression, and had used an SSRI or SNRI for at least six weeks but were still depressed. 241 were randomised to mirtazapine and 239 to placebo, both given in addition to usual SSRI or SNRI treatment. Participants were stratified by centre and minimised by baseline Beck depression inventory score, sex, and current psychological therapy. Th

United kingdomCaroline jenkinsonMary carterIanm andersonDalan montgomeryMarie plattDavids kesslerStephaniej macneillWilliam hollingworthSimon daviesJohn campbellSue jonesUna macleodGlyn lewisTom shepherdTimj peters

The great weight debate: Researchers find all

Whether you use heavy or light weights, lifting them as many times as you can builds strength and muscle. The details of how you go about it are less important than simply making a habit of it, researchers have determined. After studying the most popular variables among resistance training programs – how much you lift, how often, and how many times – kinesiologists at McMaster University have found all forms of resistance training are beneficial, including body-weight exercises such as planks, lunges and push-ups.

United kingdomCity ofAlexander graham bellRoquette freresBradley currierJonathan mcleodStuart phillipsOntario centre of innovationNational scienceMaster programCanada researchUs national dairy councilNestle health sciencesCanadian institutes for health researchEngineering research councilNatural sciences

Inequalities in provision of hip and knee replacement surgery for osteoarthritis by age, sex, and social deprivation in England between 2007–2017: A population-based cohort study of the National Joint Registry

Author summary Why was this study done? Joint replacements are among the more frequent elective surgeries performed in developed settings. In England, inequalities in provision of joint replacement surgery were reported more than a decade ago, followed by a national effort to reduce these inequalities. In a context of increasingly strained National Health Service funding and hospital budgets, alongside prolonged efforts to increase surgical capacity, it is unclear what impact these have had on inequalities in provision of joint replacement for osteoarthritis. What did the researchers do and find? We conducted an analysis of the National Joint Registry using all primary hip and knee replacements for osteoarthritis performed from 2007 to 2017 in England, merged with the Office for National Statistics official population statistics, to investigate inequalities in provision of surgery according to deprivation by patient area of residence, age, sex, and trends in these inequalities ov

City ofUnited kingdomNorthern irelandUnited statesDistrict of columbiaCeramtec gmbSanjay basuFreshfields bruckhaus deringerDepartment of healthFair society healthyNational joint registryHealthcare quality improvement partnershipNational joint registry steering committeeWhile the united kingdom national health serviceNational institute of health researchNational health service

Police-reported suicides during the first 16 months of the COVID-19 pandemic in Ecuador: A time-series analysis of trends and risk factors until June 2021

Police-reported suicides during the first 16 months of the COVID-19 pandemic in Ecuador: A time-series analysis of trends and risk factors until June 2021
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Eteläuomen läiMatthew spittalLippincott williamsDavid gunnellStuart leskeQueensland healthAustralian research council future fellowshipNational police of ecuadorBiomedical research centre at university hospitals bristolMinistry of healthUnited nationsNational institute of censusNational directorate of crimesNational policeNational institute for health researchNational directorate of crimes against life

Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: A UK cohort study

Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: A UK cohort study
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White houseDistrict of columbiaUnited statesCity ofUnited kingdomNorthern irelandAmerican society of anaesthesiologistsBiomedical research centre at university hospitals bristolSciences for depuyNational health serviceDepartment of healthUniversity of bristolInternational classificationNational joint registry steering committeeHealthcare quality improvement partnershipWorld health organization