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2Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania 3Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan 4Muhimbili National Hospital, Dar es Salaam, Tanzania HIV human immunodeficiency virus type I (HIV-1) entry inhibitor potency is dependent on viral co-receptor tropisms and thereby tropism determination is clinically important. However, phenotypic tropisms of HIV-1 non-B subtypes have been poorly investigated and the genotypic prediction algorithms remain insufficiently validated. To clarify this issue, we recruited 52 treatment-naïve, HIV-1-infected patients in Tanzania, where multiple HIV-1 non-B subtypes co-circulate. Sequence analysis of 93 infectious envelope clones isolated from their plasma viral RNA revealed the co-circulation of subtypes A1, C, D, and inter-subtype recombinant forms (isRFs). Phenotypic tropism assays revealed that lentivirus reporters pseudotyped with 75 (80.6%) and 5 (5.4%) envelope clones could e

Mbeya regionMnazi mmojaPemba northUnited statesSouth africaDar es salaamAfrica amogneSciences ref noMuhimbili university of healthTerumo foundation for life sciencesSedia bioscience corporationJapan agency for medical researchMuhimbili national hospitalMinistry of educationScientific researchSenate research