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Subscriber only Babycino in hand and his pint-sized boots full of sand, little Lachlan Passfield is having the time of his life at his first Beef Australia. It s the second time for sister Sophie who s also come in with their parents from Banana. BEEF AUSTRALIA 21: Brad and Rachel Passfield from Banana with Lachlan and Sophie It s a great family environment, said dad Brad, who works for Hourn and Bishop livestock agents. They had a great time at the Kidzone but Lachlan spends most the day in a giant sandpit he discovered outside the ring. BEEF AUSTRALIA 21:Lachlan Passfield from Banana
Immuno-Oncology In Vitro Assays
By Ben Tyrrell and Katie Chapple, Sartorius Stedim Biooutsource
We offer a wide range of assay types and formats to characterize immune-oncology monoclonal antibodies (mAbs). In this application note, we discuss our recently developed assay format to characterize checkpoint inhibitor mAbs, specifically discussing those that target the PD-1 PD-L1 pathway.
Targeting immune checkpoints such as the PD-1 PD-L1 pathway has proven in recent years to be an effective treatment approach resulting in a range of approved mAbs that bind PD-1 or its ligand PD-L1. The checkpoint inhibitor pathways continue to be an area of intensive research and development to bring other Mab treatments to the market. Characterizing the mechanism of action (MoA) of these molecules requires complex assays using primary cells because the MoA rely upon the interaction between T cells and antigen presenting cells.