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X-ray Ptychography performed for first time at small-scale Laboratory Source

X-ray Ptychography performed for first time at small-scale Laboratory Source
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Darren bateyPaul quinnGhent university creditUniversity college londonDiamond light source ltdUniversity of sheffield soft matter analytical laboratoryLaboratoryx rayGhent universityUniversity of sheffieldDiamond light sourcePhysical review lettersBeamline scientistSheffield soft matter analytical laboratoryடேரன் பேட்டிபால் க்வின்பல்கலைக்கழகம் கல்லூரி லண்டன்

Can X-ray Ptychography be used in Smaller Laboratory Source Facilities?

May 12 2021 X-ray ptychography has recently opened up applications across physical and life sciences at large-scale synchrotron facilities such as the UK’s Diamond Light Source, by producing quantitative phase images with the highest possible spatial resolutions (10’s nm) – going well beyond the conventional limitations of the available X-ray optics. Now an international collaboration of scientists has demonstrated for the first time how the technique of high-resolution phase contrast diffraction imaging can be performed with small-scale laboratory sources. The team from Diamond Light Source, Ghent University, University of Sheffield, and University College London conducted an experiment with a compact liquid metal-jet (LMJ) X-ray source. Laboratory X-ray sources have significantly lower levels of brilliance but currently provide the X-ray synchrotron user community with access to micro-CT, where they can gain a great deal of experience and produce pr

United kingdomFrederic van asschePaul quinnOleksandro mykhaylykAndrewj parnellChristoph rauSander vanheuleDarren bateyDarrenj bateySilvia cipicciaUniversity college londonLaboratory sourceMatter analytical laboratoryDepartment of medical physicsLaboratoryx rayGhent university

Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors

share: This news release, originally issued by Diamond Light Source, describes a template for how to develop directly-acting antivirals that would combat COVID-19. The study focused on a specific part of the Nsp3 gene that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. Researchers from the University of California used the Highly Automated Macromolecular Crystallography (AMX) and the Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines at the National Synchrotron Light Source II (NSLS-II) to characterize the molecular structure of proteins involved in this mechanism. The beamlines ultrasmall yet powerful x-rays and rapid sample mounting automation enabled the researchers to collect hundreds of high-resolution datasets per eight-hour shift. NSLS-II is a U.S. Department of Energy (DOE) Office of Science User Facility at DOE’s Brookhaven National Laboratory that offers a comprehensive suite of life science research capabilities. For

United statesUniversity of california san franciscoCara laaschUniversity of californiaUniversity of oxfordUs department of energyOffice of science user facilityNational synchrotron light sourceStructural biology consortiumBrookhaven national laboratoryDiamond light sourceHighly automated macromolecular crystallographyScience user facilityNational laboratoryFragment screen points wayBeamline scientist

Massive fragment screen points way to new SARS-CoV-2 inhibitors

Experiment with 2533 fragments compounds generates chemical map to future antiviral agents  Principal Beamline Scientist on I04, Frank von Delft.  New research published in Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This part of the virus’s machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking it with a drug would have the same effect. 

University of oxfordStructural biology consortiumUniversity of california san franciscoBeamline scientistScience advancesBiology consortiumCalifornia sanDrug discoveryMedicinal chemistryAntiviral drugMolecular modellingNatural sciencesProtein structureX ray crystallographyபல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட்பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening
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Angela betsaidab laguipoAngela betsaidaScience advancesBeamline scientist