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Objectives To quantify mortality rates for patients successfully treated for hepatitis C in the era of interferon-free, direct acting antivirals and compare these rates with those of the general population. Design Population based cohort study. Setting British Columbia, Scotland, and England (England cohort consists of patients with cirrhosis only). Participants 21 790 people who were successfully treated for hepatitis C in the era of interferon-free antivirals (2014-19). Participants were divided into three liver disease severity groups: people without cirrhosis (pre-cirrhosis), those with compensated cirrhosis, and those with end stage liver disease. Follow-up started 12 weeks after antiviral treatment completion and ended on date of death or 31 December 2019. Main outcome measures Crude and age-sex standardised mortality rates, and standardised mortality ratio comparing the number of deaths with that of the general population, adjusting for age, sex, and year. Poisson regressi

United kingdomWilliam irvingData access request serviceMidlands research ethics committeeAnalysis serviceResearch foundationNational cancer registrationNational strategic group for viralServices planBehavioural research ethics boardNational ambulatory care reporting systemPublic health scotlandPrivacy public benefit panel for healthBc vital statistics agencyBc vital statistics agency death registryTissue data access committee