A group of scientists from Basel University Hospital have designed an antibody-drug conjugate (ADC) that eliminated blood cancer cells without attacking healthy hematopoietic stem cells (HSCs), which they modified by base editing and transplanted to renew an altered blood system. They achieved this by focusing on the panhematopoietic marker CD45.
Selective and complete eradication of leukemic cells with an ADC targeting the pan-blood marker CD45 Engineered hematopoietic Stem Cells (HSCs) shielded from the CD45-targeting ADC maintain
It doesn't take much LSD, short for lysergic acid diethylamide, to substantially alter a person's state of consciousness. Compared with many other substances, the amounts are very small, says Dr Volker Auwärter, director of the forensic toxicology laboratory at the University of Freiburg Medical Centre in Germany: "Upwards of 50, 100 micrograms are said to be a psychedelic dose." The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) calls the hallucinogen "one of the most potent d
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