The woman died after the blaze at her home at Ballyrickard Road, near Larne.
The fire took hold at the farmhouse on Saturday afternoon.
Emergency services including the NI Fire and Rescue Service (NIFRS) and the NI Ambulance Service (NIAS) attended the scene.
Three fire service appliances and two officers were tasked.
The charity air ambulance was also scrambled to the scene.
Firefighters quickly brought the blaze under control, and the pensioner - who was in her 80s - was rushed to hospital, but died a short time later.
The PSNI said: The fire was reported to police at around 1pm on Saturday afternoon and the woman was taken to hospital for treatment but sadly passed away a short time later.
Woman in 80s dies after house fire in Larne
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Woman dies after house fire in Co Antrim
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Female pensioner in her 80s dies following Larne house fire
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