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Visiting coach Johnson Smith handed young midfielder Emmanuel Sarkodie a starting opportunity to debut for the club while also bringing Samuel Frimpong, Abdul Ganiyu and Habib Mohammed into the starting line-up
Medeama coach Samuel Boadu handed attacking responsibilities to Kwasi Donsu, Kwadwo Asamoah, Rashid Nortey and Eric Kwakwa in his set-up.
Before the match could witness any clear scoring chance, the home side were forced into an early substitution as Ali Ouattara went down injured and had to be replaced by Baba Musah in the 12th minute.
In the 16th minute, Kwakwa s shot from outside the box went off target, moments before Kotoko goalkeeper Razak Abalora denied Patrick Yeboah the opener.