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Dec 18, 2020 Treatment approach has potential disease-free survival advantage Patients with locally advanced rectal cancer treated with total neoadjuvant therapy followed by surgery had a higher chance of achieving a pathologic complete response than those treated with standard therapy involving concurrent chemotherapy followed by surgery and adjuvant chemotherapy, a meta-analysis of 7 trials involving more than 2,400 patients revealed. The pooled prevalence of pathologic complete response (PCR) was 29.9% in the total neoadjuvant therapy (TNT) patients and 14.9% in the standard treatment group. Surgical outcomes, including rates of sphincter-preserving surgery and ileostomy, did not differ significantly between the two treatment groups, and just 3 studies included data on disease-free survival while none included data on overall survival.

United statesPsalynn boylesNoam vanderwaldeAxel grotheyResearch instituteKansas university medical centerTennessee west cancer centerAnup kasiWest cancer centerContributing writerஒன்றுபட்டது மாநிலங்களில்ஆராய்ச்சி நிறுவனம்கன்சாஸ் பல்கலைக்கழகம் மருத்துவ மையம்டென்னசி மேற்கு புற்றுநோய் மையம்அனுப்பி காசிமேற்கு புற்றுநோய் மையம்