The Upper Chongwe River Catchment has recently been overexploited for water resources with increased complaints by various water users about the deteriorating quality of surface water within the sub-catchment. This study was motivated by the need to investigate and understand the response of surface water quality to land use land cover (LULC) change due to urbanization. Water samples, collected at 9 sampling sites from 2006 to 2017, were analyzed for water quality using the weighted arithmetic water quality index and trend using the Mann-Kendall statistics. LULC change is detected and analyzed in ERDAS Imagine 2014 and ArcGIS 10.4 using 2006 Landsat 5 TM and 2017 Landsat 8 OLI imageries. The relationship between LULC change and water quality was performed with multiple regression analysis and Pearson correlation. The results reveal that Built-up area, Grassland and surface water increased by 5.48%, 13.34% and 0.03% respectively while Agricultural land and Forest Land decreased by −13