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(0) Primary study endpoint demonstrates 86 percent response rate for patients receiving co-therapy of KRYSTEXXA and mycophenolate mofetil
Horizon Therapeutics plc (Nasdaq: HZNP) announced the publication of data from the first randomized controlled clinical trial (RCT) of KRYSTEXXA (pegloticase injection) concomitantly used with an immunomodulator, mycophenolate mofetil, in
Arthritis Rheumatology [doi.org/10.1002/art.41731].
The Reducing Immunogenicity of Pegloticase (RECIPE) trial demonstrated that 86 percent of patients (19 of 22) receiving co-therapy of KRYSTEXXA with the immunomodulator mycophenolate mofetil achieved serum uric acid (sUA) 6 mg/dL at 12 weeks, the primary study endpoint, compared to 40 percent of patients (4 of 10) receiving KRYSTEXXA monotherapy. The safety and efficacy of KRYSTEXXA co-prescribed with mycophenolate mofetil has not been established by any health authorities.
Risk Factors for Lung Problems With RA
Much is still not known about the connection between RA and ILD, but recent research has identified new risk factors:
Being Male Although more women get RA than men, men are at higher risk than women for developing RA-ILD, according to the Arthritis Foundation. “We need more research to find out why this is so,” says Dr. Sparks. “It could be genetic or that men tend to have a more aggressive severity of RA.”
Long-Term History of Smoking The Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) presented an abstract at the ACR conference that found that smoking above a threshold of 30 pack-years (for example, one pack per day for 30 years or 2 packs per day for 15 years) was strongly associated with RA-ILD. Sparks was a member of this team.