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Passive smoking among women during childhood and/or adulthood was associated with an increased risk for the development of rheumatoid arthritis (RA), according to a French prospective study.
This risk is particularly notable among patients who are positive for anti-citrullinated protein antibodies and those who carry the HLA-DRB1 shared epitope alleles, said Yann Nguyen, MD, of Université Paris Sud in Villejuif, France, at the European League Against Rheumatism virtual congress.
Citrullination of proteins with the conversion of the amino acid arginine to citrulline at the airway mucosal surface is recognized as one of the earliest events leading to RA.
Researchers develop novel targeted therapy for triple-negative breast cancer
Researchers from Hong Kong Baptist University (HKBU), in collaboration with Cornell University, have developed a novel targeted therapy for triple-negative breast cancer (TNBC) that uses a specially-designed nano-carrier to deliver the Chinese medicine compound gambogic acid (GA).
The invention enhances the anti-cancer effect of GA and reduces its damage to off-target organs. The invention has the potential to become a more effective therapeutic option for TNBC.
The study was supported by the Vincent and Lily Woo Foundation, and the research findings have been published in the international medical journal Frontiers in Oncology.
In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown.