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(2) NEW YORK CITY (dpa-AFX) - Today s Daily Dose brings you news about Lexicon s regulatory update on Sotagliflozin in heart failure; FDA approval of Pfizer s XALKORI in a new indication; Bicycle s pipeline progress update and Organogenesis progress in knee osteoarthritis trial. Read on. 1. Bicycle Rides High on Pipeline Progress Update Shares of Bicycle Therapeutics plc (BCYC) touched a new high on Thursday on the back of its pipeline progress update. The company s lead drug candidate BT1718 is progressing in the phase IIa portion of the Cancer Research UK sponsored phase I/IIa clinical trial in patients with advanced solid tumors. Enrollment in two solid tumor cohorts, one in squamous non-small cell lung cancer (NSCLC) and the other in an all-comers basket cohort is ongoing at four clinical sites, with additional sites expected to begin enrolling patients during the first half of 2021.

United statesUnited kingdomOrganogenesis holdings incBionano genomics incOcugen incLexicon pharmaceuticals incViveve medical incGeneration bio coCalithera biosciences incPfizer incCancer research united kingdomDaily doseRides highPipeline progress updateBicycle therapeuticsLexicon pharmaceuticals