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6 Some studies revealed that lncRNAs are related to the development and progression of DN.
7–9 For example, lncRNA MALAT1 can regulate renal tubular epithelial pyroptosis by modulating miR-23c targeting of ELAVL1 in DN.
10 LncRNA Tug1 can regulate mitochondrial bioenergetics in DN.
3 Moreover, lncRNA PVT1 (PVT1) has been shown to be involved in accelerating the progression of DN by promoting ECM accumulation and increasing expression of fibronectin 1 (FN1).
11 However, the underlying mechanism of PVT1 on diabetic nephropathy remains unclear.
MicroRNAs (miRNAs) are non-coding RNAs with 20–30 nucleotides that can bind to mRNA to regulate its protein expression.
12 Previous reports indicated that miRNA-325-3p can suppress inflammation and fibrosis in the progression of DN.