Up-front treatment with antibiotics may be appropriate in select patients with uncomplicated appendicitis, especially the surgically unfit, although appendectomy remains as first-line treatment for most others.
Antibiotics are now an accepted first-line treatment for most people with appendicitis, according to final results of the Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) trial, and an updated treatment guideline for appendicitis from the American College of Surgeons.