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“Over the last decade, spiny mice have emerged as a key animal model that can bridge regenerative biology and medicine,” said Ashley Seifert, Ph.D., an associate professor in the UK College of Arts and Sciences’ Department of Biology. He teamed up with scientists in Germany and the Netherlands to tease apart how identical injuries in two different rodent species lead to regenerative healing in one case but not the other.
Why do some animals regenerate lost tissues after injury while others don’t? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question. They compared and modulated the injury responses of these mice and common laboratory mice, that show scarring upon injury. This revealed that ERK signalling is a crucial molecular switch between scarring and regeneration. The results of this study will be published on April 26th in the scientific journal Science Advances and imply that modulation of ERK signalling could potentially be used to stimulate regeneration in a clinical setting.